Protein Details: Small conductance calcium-activated potassium channel protein 3

Protein ID

ICDB_Pro_1661

Protein Name

Small conductance calcium-activated potassium channel protein 3

Gene Name

KCNN3; K3

Organism

Homo sapiens (Human)

Length

731 amino acids

AlphaFoldDB

AF-Q9UGI6-F1-model_v4.pdb

Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)

Sequence

MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Zimmermann-Laband Syndrome 3 and Zimmermann-Laband Syndrome 1

Location

DOI ID

10.1038/sj.mp.4000353; 10.1007/s100380170046; 10.1038/sj.mp.4001271; 10.1038/nature04727; 10.1101/gr.2596504; 10.1074/jbc.m110.110072; 10.1016/j.ajhg.2019.04.012; 10.1016/j.jhep.2015.11.027

RefSeq

NP_001191016.1; NP_002240.3 [Q9UGI6-1]; NP_740752.1 [Q9UGI6-2]